Berikut adalah daftar nama pemain timnas Ghana di Piala Afrika 2021 lengkap usia dan klub saat ini.
| No | Posisi | Pemain | Usia | Klub Saat Ini |
|---|---|---|---|---|
| 1 | GK | Abdul Manaf Nurudeen | 22 | Eupen |
| 12 | GK | Lawrence Ati-Zigi | 25 | St. Gallen |
| 16 | GK | Joe Wollacott | 25 | Swindon Town |
| 24 | GK | Richard Attah | 26 | Hearts of Oak |
| 2 | DF | Andy Yiadom | 30 | Reading |
| 3 | DF | Philomon Baffour | 20 | Dreams |
| 4 | DF | Jonathan Mensah | 31 | Columbus Crew |
| 14 | DF | Gideon Mensah | 23 | Bordeaux |
| 17 | DF | Baba Rahman | 27 | Reading |
| 18 | DF | Daniel Amartey | 27 | Leicester City |
| 23 | DF | Alexander Djiku | 27 | Strasbourg |
| 26 | DF | Abdul Mumin | 23 | Vitória Guimarães |
| 5 | MF | Thomas Partey | 28 | Arsenal |
| 6 | MF | Edmund Addo | 21 | Sheriff Tiraspol |
| 8 | MF | Daniel-Kofi Kyereh | 25 | St. Pauli |
| 11 | MF | Mubarak Wakaso | 31 | Shenzhen |
| 15 | MF | Joseph Paintsil | 23 | Racing Genk |
| 20 | MF | Mohammed Kudus | 21 | Ajax |
| 21 | MF | Iddrisu Baba | 25 | Mallorca |
| 28 | MF | David Abagna | 23 | Real Tamale |
| 7 | FW | Abdul Fatawu Issahaku | 17 | Dreams |
| 9 | FW | Jordan Ayew | 30 | Crystal Palace |
| 10 | FW | André Ayew | 32 | Al-Sadd |
| 13 | FW | Richmond Boakye | 28 | Beitar Jerusalem |
| 19 | FW | Samuel Owusu | 25 | Al-Fayha |
| 22 | FW | Kamaldeen Sulemana | 19 | Rennes |
| 25 | FW | Benjamin Tetteh | 24 | Yeni Malatyaspor |
| 27 | FW | Maxwell Abbey Quaye | 23 | Great Olympics |