Berikut adalah daftar nama skuad Senegal di Piala Afrika 2021 lengkap dengan klub asal pemain tersebut.
| No | Posisi | Pemain | Usia | Klub |
|---|---|---|---|---|
| 1 | GK | Seny Dieng | 27 | Queens Park Rangers |
| 16 | GK | Édouard Mendy | 29 | Chelsea |
| 23 | GK | Alfred Gomis | 28 | Rennes |
| 2 | DF | Saliou Ciss | 32 | Nancy |
| 3 | DF | Kalidou Koulibaly | 30 | Napoli |
| 4 | DF | Pape Abou Cissé | 26 | Olympiacos |
| 14 | DF | Abdoulaye Seck | 29 | Antwerp |
| 20 | DF | Bouna Sarr | 29 | Bayern Munich |
| 21 | DF | Ibrahima Mbaye | 27 | Bologna |
| DF | Abdou Diallo | 25 | Paris Saint-Germain | |
| DF | Fodé Ballo-Touré | 25 | Milan | |
| 5 | MF | Idrissa Gueye (vice-captain) | 32 | Paris Saint-Germain |
| 6 | MF | Nampalys Mendy | 29 | Leicester City |
| 7 | MF | Pape Gueye | 22 | Marseille |
| 8 | MF | Cheikhou Kouyaté | 32 | Crystal Palace |
| 12 | MF | Moustapha Name | 26 | Paris |
| 17 | MF | Pape Matar Sarr | 19 | Metz |
| 22 | MF | Mamadou Loum | 25 | Alavés |
| 9 | FW | Boulaye Dia | 25 | Villarreal |
| 10 | FW | Sadio Mané | 29 | Liverpool |
| FW | Keita Baldé | 26 | Cagliari | |
| 11 | FW | Habib Diallo | 26 | Strasbourg |
| 13 | FW | Bamba Dieng | 21 | Marseille |
| 18 | FW | Ismaïla Sarr | 23 | Watford |
| 19 | FW | Famara Diédhiou | 29 | Alanyaspor |
| FW | Mame Thiam | 29 | Kayserispor |