Cheste, Sunday, November 14, 2021
| Pos | Rider | Team | Time |
|---|---|---|---|
| 1 | Francesco BAGNAIA | Ducati Lenovo Team | 41’15.481 |
| 2 | Jorge MARTIN | Pramac Racing | +0.489 |
| 3 | Jack MILLER | Ducati Lenovo Team | +0.823 |
| 4 | Joan MIR | Team SUZUKI ECSTAR | +5.214 |
| 5 | Fabio QUARTARARO | Monster Energy Yamaha MotoGP | +5.439 |
| 6 | Johann ZARCO | Pramac Racing | +6.993 |
| 7 | Brad BINDER | Red Bull KTM Factory Racing | +8.437 |
| 8 | Enea BASTIANINI | Avintia Esponsorama | +10.933 |
| 9 | Aleix ESPARGARO | Aprilia Racing Team Gresini | +12.651 |
| 10 | Valentino ROSSI | Petronas Yamaha SRT | +13.468 |
| 11 | Franco MORBIDELLI | Monster Energy Yamaha MotoGP | +14.085 |
| 12 | Andrea DOVIZIOSO | Petronas Yamaha SRT | +16.534 |
| 13 | Alex MARQUEZ | LCR Honda CASTROL | +17.059 |
| 14 | Miguel OLIVEIRA | Red Bull KTM Factory Racing | +18.221 |
| 15 | Iker LECUONA | Tech 3 KTM Factory Racing | +19.233 |
| 16 | Maverick VIÑALES | Aprilia Racing Team Gresini | +19.815 |
| 17 | Luca MARINI | SKY VR46 Avintia | +28.860 |
| 18 | Danilo PETRUCCI | Tech 3 KTM Factory Racing | +32.169 |
| NC | |||
| Alex RINS | Team SUZUKI ECSTAR | 17 Laps | |
| Takaaki NAKAGAMI | LCR Honda IDEMITSU | 23 Laps |